PrEP means Pre-Exposure Prophylaxis, and it’s the use of anti-HIV medication that keeps HIV-negative people from becoming infected. PrEP is approved by the FDA and has been shown to be safe and effective. A single pill taken once daily, it is highly effective against HIV when taken every day. The medication interferes with HIV’s ability to copy itself in your body after you’ve been exposed. This prevents it from establishing an infection and making you sick.

Even though PrEP has been around in the U.S. for over a year, not a lot of people know about it. And, even fewer people feel like they know enough about it to be able to make an informed decision about whether or not to use it. For those who do use it, the information they have might be more focused on practical issues, like where to get it, rather than on what PrEP does in the body to prevent HIV infection.

By using animation to show PrEP in the body and why “once a day” is recommended, people can see what PrEP does and people who currently use PrEP can create an image of what happens when they take a PrEP pill every day.

View the video below to get information about PrEP and see an illustration of how it can work inside the body to prevent HIV infection.

There are two types of programs that help people access their prescription drugs for pre-exposure prophylaxis (PrEP). One of the programs, the medication assistance program (MAP), provides free drug to those without health insurance or prescription drug coverage. The other, a drug co-pay program, provides assistance with out-of-pocket costs (including co-pays, co-insurance and deductibles) for people who have insurance.

MAPs and Copays for PrEP may have limits on the amount of money a person may earn each year to qualify for the program. This income limit is not a fixed amount. Instead, it is based on the federal poverty level (FPL) for a given household. People with more people in the household may have higher household incomes than people with fewer people in the household. For instance, people with a single person in their household may earn up to approximately $58,000 per year if the income limit is 500% of the FPL.

  • Income below 500% of the FPL (about $58,000/yr or less for a single person) and no other sources for health insurance or prescription coverage (reevaluated on a regular basis).
  • Have a prescription for Truvada
  • U.S. residency proof is required, but not immigration legal status
  • Income verified
  • Drugs shipped to provider’s office – may take two weeks
  • Contact: 1-855-330-5479
  • Gilead Co-pay Program for Truvada
  • $300 per month
  • Deductible and co-insurance coverage is limited to $300 per month
  • People must have private insurance
  • This program does not cover individuals with Medicaid or Medicare
  • No income requirement
  • Issues a co-pay card for use at pharmacies
  • Works with most pharmacies but reimburses when pharmacies don’t accept the card. Some mail-order pharmacies also don’t accept co-pay cards
  • or 1-877-505-6986
  • $4,000 per year – may reapply, but program funding will dictate response
  • Does cover deductibles and co-insurance and is designed for those who’s out-of-pocket costs are not fully covered by the Gilead program
  • Income below 500% of FPL
  • People must have private insurance
  • This program does not cover individuals with Medicaid, but it does cover those with Medicare
  • Most pharmacies should be able to bill PAN directly
  • or 1-866-316-PAN

Schedule an appointment with a Health Care Navigator at The Center to explore affordable health care plans through the Affordable Care Act Marketplace. The navigator will explain all of your options and help you sign up. The appointment is FREE. Go to, search zip code 32803, and the Center is the third option from the top.
Gilead Answers App (A HIV/AIDS & PrEP resource)
GoodRX App (lowest prescription prices in your area)
The Body App (A HIV/AIDS resource)

Pre = antes (previa)
Exposición = tener contacto con el VIH
Profilaxis = tratamiento para prevenir que ocurra una infección

La profilaxis Pre-exposición (PrEP, siglas en inglés) es una estrategia de prevención de la infección con el VIH donde los individuos VIH negativos toman medicamentos anti-VIH antes de entrar en contacto con el VIH para reducir su riesgo de infectarse. Los medicamentos previenen que el VIH establezca una infección dentro del cuerpo.

PrEP ha demostrado reducir el riesgo de infección con el VIH a través del contacto sexual en los hombres gay y bisexuales, mujeres transgénero y en hombres y mujeres heterosexuales, así como en personas que se inyectan drogas.

No protege contra otras infecciones de transmisión sexual (ITS) ni tampoco previene el embarazo. No es una cura para el VIH.

Vea el video a continuación para obtener información sobre PrEP y vea una ilustración de cómo puede funcionar dentro del cuerpo para prevenir la infección por el VIH.


Post-Exposure Prophylaxis, or PEP, is another name for emergency HIV treatment. PEP is not a cure for HIV, it is a form of HIV prevention. It is a short course of antiretroviral drugs that stops exposure to HIV from becoming a life-long infection.

PEP drugs given at this time may help the body’s immune system to stop the virus from replicating (multiplying) in the infected cells of the body. The cells originally infected would then die naturally within a short period of time without producing more copies of HIV.

It means taking antiretroviral medicines (ART) after being potentially exposed to HIV to prevent becoming infected. PEP must be started within 72 hours after a recent possible exposure to HIV, but the sooner you start PEP, the better. PEP is effective in preventing HIV when administered correctly, but not 100%.

PEP normally consists of three anti-HIV drugs, from two of the different classes. The most recent UK guidelines recommend using Truvada (a fixed-dose combination tablet combining emtricitabine and tenofovir) from the NRTI class, and raltegravir (Isentress) from the integrase inhibitor class.

It is very important to take your doses on time. When PEP fails to destroy HIV, it is often because of missed doses. PEP has side effects, which can vary from person to person. The most common side effects include nausea, vomiting, diarrhea, headaches and fatigue.

PrEP (Pre-Exposure Prophylaxis) PEP (Post-Exposure Prophylaxis) PrEP is a daily pill for HIV-negative people that can help prevent HIV infection before exposure to the virus. PEP is an emergency medication for HIV-negative people that can help prevent infection after exposure to HIV.


For timely answers for urgent HIV exposure management call: The Clinician Consultation Center PEPLINE – Phone Consultation 
(888) 444-4911 | 9:00 a.m. – 2:00 a.m. (EST), seven (7) days a week.

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